Which medication is known to cause urine discoloration?

Rifampin is well-known for causing urine discoloration, specifically transforming it into a reddish-orange color. This occurs because rifampin is a potent antibiotic that interferes with bacterial RNA synthesis. It is frequently prescribed to treat infections like tuberculosis. The change in urine color is a harmless side effect and is due to the drug being excreted intact through the kidneys.

While some other medications can cause changes in urine color, rifampin is particularly recognized for this side effect. This helps healthcare providers and patients anticipate and recognize the effects of the medication during treatment.